Flashcards

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System

Card 1 of 6

DiseasePsychiatry/Behavioral

Major Depressive Disorder

Recall: Pathophysiology · S/Sx · Gold Standard Dx · First-line Tx · Pearl

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DiseasePsychiatry/Behavioral

Pathophysiology: Multifactorial — monoamine (serotonin/norepinephrine/dopamine) dysregulation, GABA/glutamate and neuroendocrine changes, genetics.
S/Sx: ≥2 weeks of depressed mood/anhedonia plus SIGECAPS (sleep, interest, guilt, energy, concentration, appetite, psychomotor, suicidality).
Gold Standard Dx: Clinical (DSM-5): ≥5 of 9 symptoms for ≥2 weeks, including mood or anhedonia (PHQ-9 to screen).
First-line Tx: SSRIs first-line + psychotherapy (CBT); reassess if no improvement by 4 weeks.

Screen with PHQ-9; SSRIs are first-line — assess suicidality and allow weeks for effect.