Renal

~5% of blueprint

AKI/CKD, electrolytes, nephrolithiasis, acid-base, glomerular disease.

Disease Profiles

Anatomy

Region
Retroperitoneal, ~T12–L3 (the right kidney sits lower due to the liver).
Key Structures
Cortex, medullary pyramids, renal pelvis, hilum (artery, vein, ureter); the ureters narrow at three points.
Clinical Correlation
Stones lodge at the three narrowings; flank/CVA tenderness suggests pyelonephritis.
High-Yield Pearl

Kidney stones lodge at the 3 ureteral narrowings: UPJ, pelvic brim, and ureterovesical junction.

Region
Functional unit spanning the renal cortex & medulla.
Key Structures
Glomerulus/Bowman capsule, proximal tubule, loop of Henle, distal tubule, collecting duct.
Clinical Correlation
Diuretics target specific segments; the proximal tubule is the site of Fanconi syndrome.
High-Yield Pearl

Diuretic sites: acetazolamide (PCT), loop diuretics (thick ascending limb), thiazides (DCT), K-sparing (collecting duct).

First-line drugs

All pharmacology

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