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HomePharmacologyAmlodipine

Amlodipine

Calcium Channel Blocker (Dihydropyridine)
Drug Class
Calcium Channel Blocker (Dihydropyridine)
Mechanism of Action (MOA)
Blocks L-type Ca²⁺ channels in vascular smooth muscle → arterial vasodilation → ↓ afterload.
Clinical Notes
First-line HTN and vasospastic angina. Dose-dependent peripheral edema; minimal cardiac depression vs non-DHP.
Source
FDA label (DailyMed)
All pharmacology