Amphotericin B
Polyene Antifungal- Drug Class
- Polyene Antifungal
- Mechanism of Action (MOA)
- Binds ergosterol → forms membrane pores → fungal cell death.
- Black Box Warning
- Conventional (deoxycholate) form: use only for progressive, potentially life-threatening systemic fungal infection — not for noninvasive disease (thrush, vaginal/esophageal candidiasis) in immunocompetent patients.
- Clinical Notes
- Severe systemic mycoses. 'Ampho-terrible': nephrotoxicity, infusion reactions (fever/rigors), hypokalemia/hypomagnesemia. Liposomal form is less toxic.
- Source
- FDA label (DailyMed)
Sources
Reviewed June 2026- FDA label (DailyMed) — FDA / DailyMed
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