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HomePharmacologyFluconazole

Fluconazole

Azole Antifungal
Drug Class
Azole Antifungal
Mechanism of Action (MOA)
Inhibits fungal CYP450 (14-α-demethylase) → blocks ergosterol synthesis.
Clinical Notes
Candida (thrush, vaginitis, candidemia) and cryptococcal meningitis. QT prolongation; CYP inhibitor (↑ warfarin); hepatotoxicity.
Source
FDA label
All pharmacology