Haloperidol

Typical (First-Generation) Antipsychotic

Drug Class: Typical (First-Generation) Antipsychotic
Mechanism of Action (MOA): High-potency dopamine D2 receptor antagonist.
Black Box Warning: Increased mortality in elderly patients with dementia-related psychosis.
Clinical Notes: Acute agitation/psychosis and delirium. Extrapyramidal symptoms, QT prolongation, neuroleptic malignant syndrome, tardive dyskinesia.
Source: FDA label

Sources

Reviewed June 2026

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