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HomePharmacologyMethimazole

Methimazole

Thionamide (Antithyroid)
Drug Class
Thionamide (Antithyroid)
Mechanism of Action (MOA)
Inhibits thyroid peroxidase → blocks thyroid hormone synthesis.
Clinical Notes
First-line for hyperthyroidism/Graves. Agranulocytosis and hepatotoxicity. Teratogenic in the 1st trimester (aplasia cutis) — use PTU then.
Source
FDA label

Sources

Reviewed September 2026
  1. FDA label — FDA / DailyMed

Checked against the guideline or standard reference the exam keys to. If it has moved, use Report an error below.

More Thionamide (Antithyroid) drugs

  • Propylthiouracil (PTU)
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