Nafcillin

Antistaphylococcal Penicillin

Drug Class: Antistaphylococcal Penicillin
Mechanism of Action (MOA): β-lactam resistant to staphylococcal β-lactamase → inhibits cell-wall synthesis.
Clinical Notes: MSSA (not MRSA) — skin/soft tissue, endocarditis. Oxacillin/dicloxacillin are relatives. Can cause interstitial nephritis.
Source: FDA label (DailyMed)

Sources

Reviewed June 2026

Checked against the guideline or standard reference the exam keys to. If it has moved, use Report an error below.

Got a pharmacology lecture that covers Nafcillin? Turn it into flashcards and board-style questions, free. Drop it on the home page