- 🔬Pathophysiology
- Autoantibody-mediated platelet destruction → isolated thrombocytopenia.
- 🩺Signs & Symptoms
- Mucocutaneous bleeding — petechiae, purpura, easy bruising, epistaxis; otherwise well-appearing.
- 🎯Gold Standard Diagnosis
- Isolated low platelets with normal WBC/Hgb and an otherwise normal smear (diagnosis of exclusion).
- 💊First-line Treatment
- Observe if platelets >=30 and asymptomatic; short-course corticosteroids first-line; TPO-RA or rituximab if refractory.