Alendronate

Drug Class

Bisphosphonate

Mechanism of Action (MOA)

Binds hydroxyapatite and inhibits osteoclast-mediated bone resorption → ↑ bone mineral density.

Clinical Notes

First-line for osteoporosis. Take on an empty stomach with water and stay upright ≥30 min (pill esophagitis). Osteonecrosis of the jaw and atypical femoral fractures with long-term use.

Source

FDA label

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