Colchicine

Anti-Gout (Antimitotic)

Drug Class: Anti-Gout (Antimitotic)
Mechanism of Action (MOA): Binds tubulin → inhibits microtubule polymerization → ↓ neutrophil chemotaxis and activation.
Clinical Notes: Acute gout flares and prophylaxis; also pericarditis and familial Mediterranean fever. Dose-limiting diarrhea; myopathy/neuropathy and toxicity with renal/hepatic impairment + CYP3A4/P-gp inhibitors.
Source: FDA label