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HomePharmacologyAllopurinol

Allopurinol

Xanthine Oxidase Inhibitor (Urate-Lowering)
Drug Class
Xanthine Oxidase Inhibitor (Urate-Lowering)
Mechanism of Action (MOA)
Inhibits xanthine oxidase → ↓ uric acid production.
Clinical Notes
Chronic gout urate-lowering — not for acute flares (can trigger one; cover with colchicine/NSAID). Allopurinol hypersensitivity/SJS (HLA-B*5801); avoid with azathioprine.
Source
FDA label
All pharmacology