N-Acetylcysteine

Antidote (Glutathione Precursor)

Drug Class: Antidote (Glutathione Precursor)
Mechanism of Action (MOA): Replenishes hepatic glutathione, detoxifying the reactive acetaminophen metabolite NAPQI; also a mucolytic.
Clinical Notes: Antidote for acetaminophen overdose — most effective within 8 h (dose by the Rumack-Matthew nomogram). Anaphylactoid reactions with IV use.
Source: FDA label

Sources

Reviewed September 2026

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