Nitroglycerin
Nitrate- Drug Class
- Nitrate
- Mechanism of Action (MOA)
- Releases NO → ↑ cGMP → venous (and some arterial) vasodilation → ↓ preload, ↓ myocardial O₂ demand.
- Clinical Notes
- Sublingual for acute angina. Contraindicated with PDE-5 inhibitors (sildenafil) → severe hypotension. Tolerance develops — needs a nitrate-free interval.
- Source
- FDA label
Sources
Reviewed September 2026- FDA label — FDA / DailyMed
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