- 🔬Pathophysiology
- Plaque rupture → thrombus → complete coronary occlusion → transmural ischemia/infarction.
- 🩺Signs & Symptoms
- Crushing substernal chest pain >20 min, radiates to L arm/jaw, diaphoresis, dyspnea, N/V.
- 🎯Gold Standard Diagnosis
- ECG: ST elevation ≥1 mm in ≥2 contiguous leads (higher cutoffs in V2–V3) + troponin (hs-cTn preferred). Angiography defines the culprit lesion.
- 💊First-line Treatment
- ASA + P2Y12, anticoagulation, beta-blocker, high-intensity statin; PCI <90 min (120 if transfer), else fibrinolytics. O₂ only if hypoxic.