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HomePharmacologyAspirin

Aspirin

Antiplatelet (COX Inhibitor)
Drug Class
Antiplatelet (COX Inhibitor)
Mechanism of Action (MOA)
Irreversibly acetylates COX-1 → ↓ thromboxane A2 → impaired platelet aggregation for the platelet's life (~7–10 days).
Clinical Notes
ACS and secondary prevention. GI bleeding; Reye syndrome in children with viral illness; tinnitus in salicylate overdose. The 'A' in MONA.
Source
FDA label (DailyMed)
All pharmacology