Cilostazol

Phosphodiesterase-3 (PDE-3) Inhibitor

Drug Class: Phosphodiesterase-3 (PDE-3) Inhibitor
Mechanism of Action (MOA): Inhibits PDE-3 → ↑ cAMP → vasodilation and antiplatelet effect; improves claudication walking distance.
Black Box Warning: Contraindicated in heart failure of any severity — PDE-3 inhibitors decrease survival in patients with HF.
Clinical Notes: Symptomatic relief of intermittent claudication in PAD. Headache, palpitations, diarrhea. Do not use in any degree of heart failure.
Source: FDA label (DailyMed)