PA School SurvivalDidactic Year

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PANCE Body Systems

Cardiovascular
11%
Pulmonary
9%
Gastrointestinal/Nutrition
8%
Musculoskeletal
8%
Neurology
7%
Infectious Disease
7%
Psychiatry/Behavioral
7%
Reproductive
7%
Endocrine
6%
Eyes/Ears/Nose/Throat
6%
Hematology
5%
Renal
5%
Genitourinary
4%
Dermatology
4%

Weights are study aids — verify each exam cycle.

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For educational use only. Content is AI-generated, may contain errors, and is not medical advice — always verify against current primary sources and faculty guidance before clinical use.

Home PharmacologyAlteplase (tPA)

Alteplase (tPA)

Thrombolytic

Drug Class: Thrombolytic
Mechanism of Action (MOA): Recombinant tissue plasminogen activator → converts plasminogen to plasmin → fibrin clot lysis.
Clinical Notes: Acute ischemic stroke (within the time window), massive PE, and STEMI when PCI is unavailable. Absolute contraindication: active bleeding/recent hemorrhagic stroke.
Source: FDA label

All pharmacology