Zolpidem
Non-Benzodiazepine Hypnotic ('Z-Drug')- Drug Class
- Non-Benzodiazepine Hypnotic ('Z-Drug')
- Mechanism of Action (MOA)
- Selective agonist at the BZ1 (α1) subunit of the GABA-A receptor → sedation.
- Black Box Warning
- Complex sleep behaviors (sleep-driving, sleep-walking, other activities while not fully awake) have caused serious injury and death — contraindicated after any such prior episode.
- Clinical Notes
- Short-term insomnia. Complex sleep behaviors (sleep-driving/eating); next-day impairment (lower dose in women); dependence.
- Source
- FDA label (DailyMed)
Sources
Reviewed June 2026- FDA label (DailyMed) — FDA / DailyMed
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