Infectious Mononucleosis

Infectious Disease · ~7% of blueprint

Pathophysiology: Epstein-Barr virus (EBV) infecting B lymphocytes.
Signs & Symptoms: Fever, exudative pharyngitis, posterior cervical lymphadenopathy, fatigue, splenomegaly.
Gold Standard Diagnosis: Heterophile antibody (Monospot) + atypical lymphocytes; EBV-specific serologies if needed.
First-line Treatment: Supportive care; avoid contact sports ~3–4 weeks (splenic rupture); avoid amoxicillin.

High-Yield Pearl

Amoxicillin/ampicillin in mono → morbilliform rash; avoid contact sports (splenic rupture risk).

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