Adenosine

Drug Class

Antiarrhythmic (AV Nodal Blocker)

Mechanism of Action (MOA)

Activates A1 receptors → transient AV block via ↑ K⁺ efflux / ↓ Ca²⁺ influx.

Clinical Notes

First-line to terminate stable SVT/AVNRT. Ultra-short half-life (~10 s) with a few seconds of flushing/chest pressure/asystole. Theophylline/caffeine blunt it.

Source

FDA label (DailyMed)

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