Digoxin
Cardiac Glycoside- Drug Class
- Cardiac Glycoside
- Mechanism of Action (MOA)
- Inhibits Na⁺/K⁺-ATPase → ↑ intracellular Ca²⁺ (positive inotropy); ↑ vagal tone → ↓ AV conduction.
- Clinical Notes
- Narrow therapeutic index. Toxicity: nausea, visual halos/yellow vision, arrhythmia — worsened by hypokalemia. Reverse with digoxin-immune Fab.
- Source
- FDA label (DailyMed)
Sources
Reviewed June 2026- FDA label (DailyMed) — FDA / DailyMed
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