Amiodarone
Class III Antiarrhythmic- Drug Class
- Class III Antiarrhythmic
- Mechanism of Action (MOA)
- K⁺ channel blockade prolongs repolarization (also Na⁺/Ca²⁺/β effects) → ↑ refractory period.
- Black Box Warning
- Pulmonary toxicity, hepatotoxicity, and proarrhythmia — reserve for life-threatening arrhythmias.
- Clinical Notes
- Monitor PFTs, LFTs, TFTs; very long half-life (weeks).
- Source
- FDA label
Sources
Reviewed September 2026- FDA label — FDA / DailyMed
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