Pyrazinamide
Anti-Tuberculous Agent- Drug Class
- Anti-Tuberculous Agent
- Mechanism of Action (MOA)
- Prodrug hydrolyzed to pyrazinoic acid; active only at slightly acidic pH — precise mechanism of action not established.
- Clinical Notes
- The 'P' of RIPE TB therapy (first 2 months). Hepatotoxicity and hyperuricemia (can precipitate gout). Given with rifampin, isoniazid, and ethambutol.
- Source
- FDA label
Sources
Reviewed September 2026- FDA label — FDA / DailyMed
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