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PANCE Body Systems

Cardiovascular
11%
Pulmonary
9%
Gastrointestinal/Nutrition
8%
Musculoskeletal
8%
Neurology
7%
Infectious Disease
7%
Psychiatry/Behavioral
7%
Reproductive
7%
Endocrine
6%
Eyes/Ears/Nose/Throat
6%
Hematology
5%
Renal
5%
Genitourinary
4%
Dermatology
4%

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For educational use only. Content is AI-generated, may contain errors, and is not medical advice — always verify against current primary sources and faculty guidance before clinical use.

Home PharmacologyPyrazinamide

Pyrazinamide

Anti-Tuberculous Agent

Drug Class: Anti-Tuberculous Agent
Mechanism of Action (MOA): Prodrug hydrolyzed to pyrazinoic acid; active only at slightly acidic pH — precise mechanism of action not established.
Clinical Notes: The 'P' of RIPE TB therapy (first 2 months). Hepatotoxicity and hyperuricemia (can precipitate gout). Given with rifampin, isoniazid, and ethambutol.
Source: FDA label

Sources

Reviewed September 2026

FDA label — FDA / DailyMed

Checked against the guideline or standard reference the exam keys to. If it has moved, use Report an error below.

More Anti-Tuberculous Agent drugs

Ethambutol
Isoniazid

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