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PANCE Body Systems

Cardiovascular
11%
Pulmonary
9%
Gastrointestinal/Nutrition
8%
Musculoskeletal
8%
Neurology
7%
Infectious Disease
7%
Psychiatry/Behavioral
7%
Reproductive
7%
Endocrine
6%
Eyes/Ears/Nose/Throat
6%
Hematology
5%
Renal
5%
Genitourinary
4%
Dermatology
4%

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Home PharmacologySitagliptin

Sitagliptin

DPP-4 Inhibitor

Drug Class: DPP-4 Inhibitor
Mechanism of Action (MOA): Inhibits DPP-4 → ↑ endogenous incretins (GLP-1, GIP) → glucose-dependent insulin release.
Clinical Notes: Weight-neutral with low hypoglycemia risk. Rare pancreatitis and arthralgia.
Source: FDA label (DailyMed)

All pharmacology