Sitagliptin

DPP-4 Inhibitor
Drug Class
DPP-4 Inhibitor
Mechanism of Action (MOA)
Inhibits DPP-4 → ↑ endogenous incretins (GLP-1, GIP) → glucose-dependent insulin release.
Clinical Notes
Weight-neutral with low hypoglycemia risk. Rare pancreatitis and arthralgia.

Sources

Reviewed June 2026
  1. FDA label (DailyMed) — FDA / DailyMed

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