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HomePharmacologyGlipizide

Glipizide

Sulfonylurea
Drug Class
Sulfonylurea
Mechanism of Action (MOA)
Closes pancreatic β-cell K⁺-ATP channels → depolarization → insulin secretion.
Clinical Notes
Requires functioning β-cells. Hypoglycemia and weight gain are the main risks; glyburide is riskier in the elderly/renal disease.
Source
FDA label (DailyMed)
All pharmacology