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HomePharmacologySemaglutide

Semaglutide

GLP-1 Receptor Agonist
Drug Class
GLP-1 Receptor Agonist
Mechanism of Action (MOA)
Activates GLP-1 receptors → glucose-dependent insulin secretion, ↓ glucagon, delayed gastric emptying, ↑ satiety.
Black Box Warning
Thyroid C-cell tumors in rodents — contraindicated with personal/family history of medullary thyroid carcinoma or MEN 2.
Clinical Notes
T2DM and chronic weight management; cardiovascular benefit. Nausea, weight loss, and pancreatitis risk.
Source
FDA label

Sources

Reviewed September 2026
  1. FDA label — FDA / DailyMed

Checked against the guideline or standard reference the exam keys to. If it has moved, use Report an error below.

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