Bupropion

Atypical Antidepressant (NDRI)

Drug Class: Atypical Antidepressant (NDRI)
Mechanism of Action (MOA): Inhibits norepinephrine and dopamine reuptake.
Black Box Warning: Increased suicidality in patients <25. (The separate smoking-cessation neuropsychiatric boxed warning was removed by the FDA in 2016.)
Clinical Notes: No sexual dysfunction or weight gain; aids smoking cessation. Lowers seizure threshold — avoid in seizure disorder and bulimia/anorexia.
Source: FDA label

Sources

Reviewed June 2026

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