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HomePharmacologyFluoxetine

Fluoxetine

Selective Serotonin Reuptake Inhibitor (SSRI)
Drug Class
Selective Serotonin Reuptake Inhibitor (SSRI)
Mechanism of Action (MOA)
Selectively inhibits serotonin reuptake → ↑ synaptic serotonin.
Black Box Warning
Increased suicidality in patients <25.
Clinical Notes
Long half-life — dose changes take weeks to show in plasma; activating. Potent CYP2D6 inhibitor (increases many drug levels). Approved in children/adolescents (MDD >=8 y, OCD >=7 y).
Source
FDA label

Sources

Reviewed September 2026
  1. FDA label — FDA / DailyMed

Checked against the guideline or standard reference the exam keys to. If it has moved, use Report an error below.

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