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HomePharmacologyCarbamazepine

Carbamazepine

Antiepileptic
Drug Class
Antiepileptic
Mechanism of Action (MOA)
Blocks voltage-gated Na⁺ channels → ↓ neuronal excitability.
Black Box Warning
Aplastic anemia/agranulocytosis and serious dermatologic reactions (SJS/TEN, esp. with HLA-B*1502 — screen patients of Asian ancestry).
Clinical Notes
Focal seizures and trigeminal neuralgia. SIADH/hyponatremia; potent CYP inducer (autoinduction).
Source
FDA label

Sources

Reviewed June 2026
  1. FDA label — FDA / DailyMed

Checked against the guideline or standard reference the exam keys to. If it has moved, use Report an error below.

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