Lamotrigine

Antiepileptic / Mood Stabilizer

Drug Class: Antiepileptic / Mood Stabilizer
Mechanism of Action (MOA): Blocks voltage-gated Na⁺ channels → ↓ glutamate release.
Black Box Warning: Serious rashes including Stevens-Johnson syndrome/TEN — titrate slowly.
Clinical Notes: Focal/generalized seizures and bipolar maintenance. Slow titration; valproate raises levels (↑ rash risk). Generally weight-neutral.
Source: FDA label

Sources

Reviewed June 2026

Checked against the guideline or standard reference the exam keys to. If it has moved, use Report an error below.

Got a pharmacology lecture that covers Lamotrigine? Turn it into flashcards and board-style questions, free. Drop it on the home page