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HomePharmacologyMagnesium Sulfate

Magnesium Sulfate

Electrolyte / Anticonvulsant
Drug Class
Electrolyte / Anticonvulsant
Mechanism of Action (MOA)
Membrane stabilization and NMDA-receptor antagonism (seizure prophylaxis) plus smooth-muscle relaxation (tocolysis, bronchodilation).
Clinical Notes
First-line to prevent/treat eclamptic seizures in preeclampsia; also torsades and severe asthma. Toxicity: loss of deep tendon reflexes → respiratory depression → cardiac arrest — antidote is IV calcium gluconate.
Source
FDA label (DailyMed)
All pharmacology