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Preeclampsia

Reproductive · ~7% of blueprint
Pathophysiology
Placental ischemia/hypoperfusion -> maternal endothelial dysfunction -> hypertension & proteinuria after 20 weeks.
Signs & Symptoms
New HTN ≥140/90 with proteinuria after 20 weeks; headache, visual changes, RUQ pain, edema if severe.
Gold Standard Diagnosis
BP ≥140/90 on two occasions + proteinuria (or end-organ dysfunction) after 20 weeks gestation.
First-line Treatment
Definitive treatment is delivery; magnesium sulfate for seizure prophylaxis; labetalol/hydralazine for BP.
Drug cardsMagnesium SulfateLabetalolHydralazine
High-Yield Pearl

Magnesium sulfate prevents eclamptic seizures; delivery is the only definitive treatment.

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Sources

Reviewed September 2026
  1. Aspirin Use to Prevent Preeclampsia and Related Morbidity and Mortality: Preventive Medication — U.S. Preventive Services Task Force, 2021
  2. Practice Advisory: Low-Dose Aspirin Use for the Prevention of Preeclampsia and Related Morbidity and Mortality — ACOG and SMFM, 2021
  3. StatPearls: Preeclampsia — StatPearls Publishing / NCBI Bookshelf, 2026

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