Clindamycin

Lincosamide
Drug Class
Lincosamide
Mechanism of Action (MOA)
Binds the 50S ribosomal subunit → inhibits protein synthesis (bacteriostatic).
Black Box Warning
Clostridioides difficile-associated diarrhea/colitis (ranges from mild diarrhea to fatal colitis) — reserve for serious infections where less toxic agents are inappropriate.
Clinical Notes
Anaerobes above the diaphragm, MRSA/strep skin infection, toxin suppression in nec fasc/TSS. Classic cause of C. difficile colitis.
Source
FDA label

Sources

Reviewed June 2026
  1. FDA label — FDA / DailyMed

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