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HomePharmacologyLinezolid

Linezolid

Oxazolidinone
Drug Class
Oxazolidinone
Mechanism of Action (MOA)
Binds the 50S ribosomal subunit → blocks formation of the initiation complex (bacteriostatic).
Clinical Notes
MRSA and VRE. Reversible MAO inhibition → serotonin syndrome with SSRIs; thrombocytopenia and peripheral/optic neuropathy with prolonged use.
Source
FDA label
All pharmacology