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PANCE Body Systems

Cardiovascular
11%
Pulmonary
9%
Gastrointestinal/Nutrition
8%
Musculoskeletal
8%
Neurology
7%
Infectious Disease
7%
Psychiatry/Behavioral
7%
Reproductive
7%
Endocrine
6%
Eyes/Ears/Nose/Throat
6%
Hematology
5%
Renal
5%
Genitourinary
4%
Dermatology
4%

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Home PharmacologyTrimethoprim-Sulfamethoxazole

Trimethoprim-Sulfamethoxazole

Folate Antagonist

Drug Class: Folate Antagonist
Mechanism of Action (MOA): Sequential folate-synthesis blockade (sulfamethoxazole → dihydropteroate synthase; trimethoprim → dihydrofolate reductase).
Clinical Notes: UTIs, community MRSA, PCP prophylaxis/treatment; hyperkalemia; avoid in sulfa allergy & pregnancy.
Source: FDA label (DailyMed)

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