Migraine

Neurology · ~7% of blueprint

Pathophysiology: Neurovascular disorder with cortical spreading depression and trigeminovascular activation.
Signs & Symptoms: Unilateral, pulsating, moderate–severe headache with photophobia/phonophobia and N/V; ± aura.
Gold Standard Diagnosis: Clinical diagnosis (e.g., POUND features); imaging only for red-flag features.
First-line Treatment: Acute: triptans + NSAIDs; prevention: beta-blockers, topiramate, or anti-CGRP agents.

High-Yield Pearl

Triptans are contraindicated in coronary disease & uncontrolled HTN (vasoconstriction).

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